IMMUNOHISTOCHEMICAL PROFILING OF REGIONAL LYMPH NODES IN COVID-19: INSIGHTS INTO IMMUNE RESPONSE AND POTENTIAL THERAPEUTIC TARGETS

Abstract

The COVID-19 pandemic has highlighted the necessity for an in-depth understanding of the disease's pathophysiology, particularly concerning the immunological response within regional lymph nodes. This study investigates the immunohistochemical profiling of lymph nodes in COVID-19 patients, revealing significant pathomorphological alterations such as lymphoid depletion, necrosis, and changes in immune cell populations. These modifications correlate with disease severity and may impair the immune system’s ability to effectively respond to SARS-CoV-2. By synthesizing contributions from both English and Russian literature, this article elucidates the importance of lymph nodes in immune dysregulation and identifies potential therapeutic targets. Although limitations such as a small sample size and retrospective design exist, the findings underscore the need for further research to explore the complex dynamics of immune responses in COVID-19. Ultimately, this research aims to facilitate the development of targeted interventions to improve patient outcomes.